Magnetic Resonance Imaging Diffusion Tensor Tractography for Early Osteoarthritis Assessment


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Primary Outcome Measures:
Secondary Outcome Measures:

  • Evaluation of the MRI tractography reconstructions in the assessment of early osteoarthritis using a qualitative parameter of visual information obtained from APM maps. [ Time Frame: 6 months ]

    Correlation between the qualitative parameter of visual information (heterogeneity, contrast density by fiber density) and the gold standard of the arthrosis grade(OARSI).

  • Evaluation the of the MRI tractography reconstructions in the assessment of early osteoarthritis using the Track Weighted – Apparent Diffusion Coefficient (TW-ADC) obtained from APM maps [ Time Frame: 6 months ]

    Correlation between the Track Weighted – Apparent Diffusion Coefficient (TW-ADC) and the gold standard of arthrosis grade (OARSI).

  • Evaluation of MRI tractography reconstructions in the assessment of early osteoarthritis using the Track Weighted-Anisotropy Fraction (TW-FA) obtained from APM maps. [ Time Frame: 6 months ]

    Correlation between the Track Weighted-Anisotropy Fraction (TW-FA) and the gold standard of arthrosis grade (OARSI).

  • Evaluation of MRI tractography reconstructions in the assessment of early osteoarthritis using the Track Weighted -Fibre Orientation Distribution (TW-FOD) obtained from APM maps. [ Time Frame: 6 months ]

    Correlation between the Track Weighted -Fibre Orientation Distribution (TW-FOD) and the gold standard of arthrosis grade (OARSI).

  • Evaluation of MRI tractography reconstructions in the assessment of early osteoarthritis by using the Apparent Fibre Density (AFD) obtained from APM maps. [ Time Frame: 6 months ]

    Correlation between the Apparent Fibre Density (AFD) and the gold standard of arthrosis grade (OARSI).

  • Evaluation of Optical Coherence Tomography (OCT) in the assessment of early osteoarthritis. [ Time Frame: 6 months ]

    Correlation between the qualitative parameter from OCT and the gold standard of arthrosis grade (OARSI).

  • Sub-group analysis, according to the selected Anisotropy Fraction (FA) cutoff, to assess the MRI tractography reconstructions in the assessment of early osteoarthritis. [ Time Frame: 6 months ]

    Correlation between the quantitative parameters previously cited and the gold standard of arthrosis grade (OARSI) for each group of Anisotropy Fraction (FA).

Knee osteoarthritis (OA) is a common and chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration.

More and more studies report the benefits of Magnetic Resonance (MR) diffusion tensor imaging (DTI) in the study of early knee osteoarthritis and in particular the new MRI contrasts generating the Track Weighted Imaging (TWI) technique.

In this observationnal and pilot study, we aim to evaluate, for the first time, the new MRI tractography maps for the study of early knee osteoarthritis.