Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy


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The Atkins Diet Modified (ADM) is the best alternative treatment for drug-resistant epilepsy, There is a high prevalence worldwide , especially in Latin American countries, including Mexico.

Low income earners, many of which do not have a social security, must meet the high costs by Antiepileptic Drugs (AEDS), which in addition should be used in conjunction or combination therapy, because monotherapy is insufficient .

The diet adkins makes some changes in the traditional food habits by others that are accessible and not necessarily expensive, whose mechanism allows for better control of the seizures.

Primary Outcome Measures:

Secondary Outcome Measures:

  • Therapeutic response observed in electroencephalogram [ Time Frame: 3 months ]

    Panic electroencephalographic criteria on the therapeutic response. Having regard to the standardization, improvement or worsening of the crisis in the electroencephalogram

  • Measurement of quality of life and decrease in seizures [ Time Frame: 3 months ]

    Interrogate the patient with a questionnaire of refractory epilepsy drugs. And ask to the patient with this questionnaire if improved their quality of life and have decreased seizures after using the atkins diet modified.

  • Blood tests (Hematic biometry) [ Time Frame: 3 months ]

    Take this blood test to assess the general conditions of the patient and see their levels of hemoglobin, hematocrit, leukocyte and platelet count.

  • Blood chemistry (serum electrolytes) [ Time Frame: 3 months ]

    It will evaluate the general condition of the patient and with this test rule out the presence of electrolyte imbalance

  • liver function tests [ Time Frame: 3 months ]

    Will be evaluated with this test levels of transaminases as can be raised by treatment anticonvulsant and see if there are any changes with the changes in the diet of patients

  • ketonuria [ Time Frame: 3 months ]

    It will assess the levels of ketones in urine due to the change in the diet of patients with the Atkins diet

Enrollment: 14
Actual Study Start Date: September 1, 2015
Study Completion Date: December 30, 2016
Primary Completion Date: April 30, 2016 (Final data collection date for primary outcome measure)
Active Comparator: modified adkins diet

modified adkins diet. It consists in the free intake of proteins and fats, and the restriction of carbohydrates that are gradually being installed. Its mechanism of action that induces a state of ketosis.

Other: modified adkins diet

Patients were assigned to two groups, one of them received modified adkins diet for treatment of drug-resistant epilepsy. It consists in the free intake of proteins and fats, and the restriction of carbohydrates that are gradually being installed. Its mechanism of action that induces a state of ketosis

Other Name: adkins diet in drug-resistant epilepsy

Active Comparator: Pharmacotherapy without diet

It consists in administer only pharmacological treatment withot a special diet, Drug-resistant epilepsy is characterized by the use of antiepileptic drugs and in optimal doses, depending on the type of epilepsy, at least on two consecutive occasions without response to management.

Drug: Pharmacotherapy without diet

Patients were assigned to two groups, one of them received conventional treatment with antiepileptic drugs without a special diet

Other Name: treatment with antiepileptic drugs

Objective: To assess the efficacy, tolerability and adherence of the modified adkins diet in adult patients with drug-resistent epilepsy Materials and Methods: Clinical trial, made up of patients with drug-resistent epilepsy, selected by convenience, who will be handled pharmacologically with the standard treatment of this condition for a period of not less than 6 months, after which they will be treated with adkins diet modified, prior informed consent, to establish its effect and a comparative analysis later.

The objective of this work is to analyze the efficacy, tolerability and adherence of the modified atkins diet in adult patients with drug-resistant epilepsy.