Effect of PEP on Oxygen Saturation and Carbon Dioxide After Abdominal Surgery


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PEP (positive expiratory pressure) is routinely given to patients after surgery in order to improve lung function. There is, however, no evidence of effect on lung function, postoperative pneumonia or any other outcome (Guimarães MMF, Tyson AF). We aim to test the immediate effects on oxygen saturation and carbon dioxide. 70 patients will be investigated in RCT design with deep inspirations and expression in PEP or only deep inspiration. Primary outcome: continuous oxygen saturation from pulse oximetry and transcutaneous carbon dioxide.

Condition Intervention
Blood Gas Monitoring, Transcutaneous Device: positive expiratory pressure (PEP)
Other: Placebo comparator, Deep inspiration without PEP

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Investigator, Outcomes Assessor
Primary Purpose: Treatment
Official Title: Effect of PEP on Oxygen Saturation and Carbon Dioxide After Abdominal Surgery

Resource links provided by NLM:

Further study details as provided by Karl A Franklin, Umeå University:

Primary Outcome Measures:

  • Transcutaneous blood gas measurements: transcutaneous pCO2 [ Time Frame: once, within one hour ]

    transcutaneous pCO2

Secondary Outcome Measures:

Estimated Enrollment: 80
Anticipated Study Start Date: June 7, 2017
Estimated Study Completion Date: June 7, 2018
Estimated Primary Completion Date: June 7, 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: placebo

3 cycles of 10 deep inspiration and expiration in room air without expiratory resistance

Other: Placebo comparator, Deep inspiration without PEP

Deep inspirations 3 times 10 and expiration in room air without expiratory resistance

Active Comparator: PEP

3 cycles of 10 deep inspiration followed by expiration with positive expiratory pressure (PEP)

Device: positive expiratory pressure (PEP)

Patients take a deep inspiration followed by PEP expiration with an expiratory pressure of 10-15 cm H2O

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