Reirradiation for Small Inoperable Head and Neck Tumors


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Primary Outcome Measures:
Secondary Outcome Measures:

Study Groups:

You will be randomly assigned (as in the flip of a coin) to 1 of 2 study groups. This is done because no one knows if one study group is better, the same, or worse than the other group.

  • If you are assigned to Group 1, you will receive SBRT.
  • If you are assigned to Group 2, you will receive conventional radiation therapy.

Radiation Therapy:

If you are in Group 1, you will receive SBRT every other day for a total of 5 treatments (about 2 weeks).

If you are in Group 2, you will receive conventional radiation therapy 1 time each weekday (Monday-Friday) for a total of up to 30-35 treatments (about 6-7 weeks).

Length of Study:

Your active participation in this study will be over after the follow-up visits.

Study Visits:

Immediately before and after receiving radiation treatment, you will complete the same 6 questionnaires that you did at baseline.

At each standard of care visit during your treatment:

  • You will complete the same 6 questionnaires that you did at baseline.
  • If the doctor thinks it is needed, you will have an MRI and either a CT or PET-CT scan at the Center for Advanced Biomedical Imaging to help with radiation treatment planning.

Follow-Up Visits:

About 2 months after your last radiation treatment and then every 3 months after that for up to 2 years:

  • You will complete the same 6 questionnaires that you did at baseline.
  • If the doctor thinks it is needed, you will have a CT and PET-CT scan to check the status of the disease.

This is an investigational study. Conventional radiation therapy and SBRT are delivered using FDA-approved and commercially available methods. The study doctor can explain how each method of delivering radiation is designed to work.

Up to 100 participants will take part in this study. All will be enrolled at MD Anderson.